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A 63-year-old man receiving allopurinol for gout developed progressive uremia, proteinuria, edema, and purpura after beginning quinidine therapy. A macrophage migration-inhibition test was negative in the presence of both quinidine and allopurinol. The following information includes only the average doses of allopurinol. You will need to discuss the benefits and risks of using Allopurinol  while you are pregnant. In one study in mice, large amounts of allopurinol caused birth defects and other unwanted effects. Do not use this medication if you are allergic to didanosine, or if you are also taking allopurinol (Zyloprim) or ribavirin (Rebetol, Ribasphere, Copegus Virazole).

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